Trypanothione synthetase-IN-2

• UNSPSC Description:

  Trypanothione synthetase-IN-2 (Compound 3) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 5.4 μM when triamine spermidine is as polyamine S[1].

• Target Antigen:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/trypanothione-synthetase-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCCCCCCCCCC(NC(COC(C1=CC(OCCN)=C(C(OCCN)=C1)OCCN)=O)COC(C2=CC(OCCN)=C(C(OCCN)=C2)OCCN)=O)=O

• Molecular Weight:

  836.03

• References & Citations:

  [1]Alcón-Calderón M, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022: 114675.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported