Trypanothione synthetase-IN-1

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804-HY-151148

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CAS Number: 2355349-41-4
UNSPSC Description: Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1].
Target Antigen: Parasite
Type: Reference compound
Related Pathways: Anti-infection
Applications: COVID-19-immunoregulation
Field of Research: Infection
Assay Protocol: https://www.medchemexpress.com/trypanothione-synthetase-in-1.html
Solubility: 10 mM in DMSO
Smiles: [NH3+]CCCCC1=CN(C2=CC(OCCN3CCNC3=O)=C(C=C2)C4=NC(C5=CC=C(C=C5)OC6=CC=CC=C6)=C(C7=CC=CC=C7)S4)N=N1.O=C([O-])C(F)(F)F
Molecular Weight: 785.83
References & Citations: [1]Alcón-Calderón M, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library. European Journal of Medicinal Chemistry, 2022: 114675.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-151148	Trypanothione synthetase-IN-1
HY-151149	Trypanothione synthetase-IN-4
HY-162134	Trypanothione synthetase-IN-5
HY-151151	Trypanothione synthetase-IN-3
HY-151150	Trypanothione synthetase-IN-2
HY-148205	Trypanothione
HY-152149-04	CTP Synthetase-IN-1
HY-152149-03	CTP Synthetase-IN-1
HY-152149-02	CTP Synthetase-IN-1
HY-152149-01	CTP Synthetase-IN-1

Cat	Name
T64056-1g	Trypanothione synthetase-IN-4
T64056-10mg	Trypanothione synthetase-IN-4
T64056-50mg	Trypanothione synthetase-IN-4
T64056-1mg	Trypanothione synthetase-IN-4
T64056-5mg	Trypanothione synthetase-IN-4
MBS1094207-02	Recombinant Trypanothione synthetase (TRS), partial
MBS1094207-03	Recombinant Trypanothione synthetase (TRS), partial
MBS1094207-04	Recombinant Trypanothione synthetase (TRS), partial
MBS1094207-01	Recombinant Trypanothione synthetase (TRS), partial
MBS1094207-05	Recombinant Trypanothione synthetase (TRS), partial