Trypanothione synthetase-IN-5

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804-HY-162134

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UNSPSC Description: Trypanothione synthetase-IN-5 (compound 9) is a trypanothione reductase (TR) inhibitor, with an IC50 of 20.5 μM for Leishmania infantum TR. Trypanothione synthetase-IN-5 also has inhibitory activity for human glutathione reductase (hGR), with an IC50 of 62.4 μM[1].
Target Antigen: Parasite
Type: Reference compound
Related Pathways: Anti-infection
Applications: COVID-19-immunoregulation
Field of Research: Infection
Assay Protocol: https://www.medchemexpress.com/trypanothione-synthetase-in-5.html
Solubility: 10 mM in DMSO
Smiles: O=C(N1CC[N+](C)(CC1)CCCC2=CC=CC=C2)N(CC3=CC=C(O3)C(NCCC4=CC=C(C=C4)F)=O)C5=CC=C(C=C5)F.[I-]
Molecular Weight: 728.61
References & Citations: [1]Exertier C, et al. Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J Med Chem. 2024 Jan 11;67(1):402-419.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
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Cat	Name
T64056-10mg	Trypanothione synthetase-IN-4
T64056-50mg	Trypanothione synthetase-IN-4
T64056-1g	Trypanothione synthetase-IN-4
T64056-1mg	Trypanothione synthetase-IN-4
T64056-5mg	Trypanothione synthetase-IN-4
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