Trypanothione synthetase-IN-5

• UNSPSC Description:

  Trypanothione synthetase-IN-5 (compound 9) is a trypanothione reductase (TR) inhibitor, with an IC50 of 20.5 μM for Leishmania infantum TR. Trypanothione synthetase-IN-5 also has inhibitory activity for human glutathione reductase (hGR), with an IC50 of 62.4 μM[1].

• Target Antigen:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/trypanothione-synthetase-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1CC[N+](C)(CC1)CCCC2=CC=CC=C2)N(CC3=CC=C(O3)C(NCCC4=CC=C(C=C4)F)=O)C5=CC=C(C=C5)F.[I-]

• Molecular Weight:

  728.61

• References & Citations:

  [1]Exertier C, et al. Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J Med Chem. 2024 Jan 11;67(1):402-419.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported