Isoleucyl tRNA synthetase-IN-2

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804-HY-147674

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CAS Number: 2494195-61-6
UNSPSC Description: Isoleucyl tRNA synthetase-IN-2 (compound 36a) is a potent and selective isoleucyl-tRNA synthetase (IleRS) inhibitor, with a Ki,app of 114 nM[1].
Target Antigen: Aminoacyl-tRNA Synthetase
Type: Reference compound
Related Pathways: Metabolic Enzyme/Protease
Applications: COVID-19-immunoregulation
Field of Research: Infection
Assay Protocol: https://www.medchemexpress.com/isoleucyl-trna-synthetase-in-2.html
Solubility: 10 mM in DMSO
Smiles: O[C@H]([C@@H]([C@H](OC1)COS(NC([C@@H](N)[C@@H](C)CC)=O)(=O)=O)O)[C@@H]1OCCN2C=C(C3=CC=CC=C3)N=N2
Molecular Weight: 527.59
References & Citations: [1]De Ruysscher D, et al. Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase. Bioorg Med Chem. 2020 Aug 1;28(15):115580.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-147674	Isoleucyl tRNA synthetase-IN-2
HY-147643	Aminoacyl tRNA synthetase-IN-2
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HY-108939-03	Aminoacyl tRNA synthetase-IN-1
HY-108939-02	Aminoacyl tRNA synthetase-IN-1
HY-108939-01	Aminoacyl tRNA synthetase-IN-1
HY-151150	Trypanothione synthetase-IN-2
HY-E70233-03	Histidyl-tRNA synthetase, human
HY-E70233-02	Histidyl-tRNA synthetase, human
HY-E70233-01	Histidyl-tRNA synthetase, human

Cat	Name
T63706-1mg	Isoleucyl tRNA synthetase-IN-2
T63706-1g	Isoleucyl tRNA synthetase-IN-2
T63706-50mg	Isoleucyl tRNA synthetase-IN-2
T63706-10mg	Isoleucyl tRNA synthetase-IN-2
T63706-5mg	Isoleucyl tRNA synthetase-IN-2
T63688-1mg	Isoleucyl tRNA synthetase-IN-1
T63688-10mg	Isoleucyl tRNA synthetase-IN-1
T63688-1g	Isoleucyl tRNA synthetase-IN-1
T63688-50mg	Isoleucyl tRNA synthetase-IN-1
T63688-5mg	Isoleucyl tRNA synthetase-IN-1