Trypanothione synthetase-IN-4

• UNSPSC Description:

  Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis[1].

• Target Antigen:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/trypanothione-synthetase-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[N+](C)(CC1=CC(OC)=C(C=C1)OCCCCCCCCCCCCCC)C2CCCC2.[I-]

• Molecular Weight:

  573.63

• References & Citations:

  [1]M. Alcón-Calderón, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library, European Journal of Medicinal Chemistry (2022).

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported