Trypanothione synthetase-IN-4

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804-HY-151149

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UNSPSC Description: Trypanothione synthetase-IN-4 is a L. infantum trypanothione synthetase (TryS) inhibitor, and the activity is dependent on the concentration of the polyamine substrate. Trypanothione synthetase-IN-4 has potent antileishmanicidal activity with an EC50 value of 0.6 μM and a selectivity index of 35. Trypanothione synthetase-IN-4 can be used for the research of leishmaniasis[1].
Target Antigen: Parasite
Type: Reference compound
Related Pathways: Anti-infection
Applications: COVID-19-immunoregulation
Field of Research: Infection
Assay Protocol: https://www.medchemexpress.com/trypanothione-synthetase-in-4.html
Solubility: 10 mM in DMSO
Smiles: C[N+](C)(CC1=CC(OC)=C(C=C1)OCCCCCCCCCCCCCC)C2CCCC2.[I-]
Molecular Weight: 573.63
References & Citations: [1]M. Alcón-Calderón, et al. Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library, European Journal of Medicinal Chemistry (2022).
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-151149	Trypanothione synthetase-IN-4
HY-162134	Trypanothione synthetase-IN-5
HY-151151	Trypanothione synthetase-IN-3
HY-151150	Trypanothione synthetase-IN-2
HY-151148	Trypanothione synthetase-IN-1
HY-148205	Trypanothione
HY-152149-04	CTP Synthetase-IN-1
HY-152149-03	CTP Synthetase-IN-1
HY-152149-02	CTP Synthetase-IN-1
HY-152149-01	CTP Synthetase-IN-1

Cat	Name
T64056-1g	Trypanothione synthetase-IN-4
T64056-10mg	Trypanothione synthetase-IN-4
T64056-50mg	Trypanothione synthetase-IN-4
T64056-1mg	Trypanothione synthetase-IN-4
T64056-5mg	Trypanothione synthetase-IN-4
MBS1094207-04	Recombinant Trypanothione synthetase (TRS), partial
MBS1094207-02	Recombinant Trypanothione synthetase (TRS), partial
MBS1094207-03	Recombinant Trypanothione synthetase (TRS), partial
MBS1094207-01	Recombinant Trypanothione synthetase (TRS), partial
MBS1094207-05	Recombinant Trypanothione synthetase (TRS), partial