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NC-III-49-1

CAT: 0804-HY-150683Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-150683Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor. NC-III-49-1 shows binding potential for BRD4-1, BRD4-2, BRD4-T, BRDT-1, BRDT-2, BRDT-T with Kd values of 0.095, 0.32, 0.29, 0.089, 5.5, 0.058 nM, respectively. NC-III-49-1 shows antiproliferative activity. NC-III-49-1 decreases the expression of c-Myc[1].
CAS Number
3031654-46-0
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nc-iii-49-1.html
Solubility
10 mM in DMSO
Smiles
CCS(=O)(NC1=CC=C(C(C(C2=C3C=CC=C2)=CN(C3=O)C)=C1)OCCOCCOCCOCCOC4=CC=C(C=C4C(C5=C6C=CC=C5)=CN(C6=O)C)NS(CC)(=O)=O)=O
Molecular Formula
C44H50N4O11S2
Molecular Weight
875.02
References & Citations
[1]Guan X, et al. Bivalent BET Bromodomain Inhibitors Confer Increased Potency and Selectivity for BRDT via Protein Conformational Plasticity. J Med Chem. 2022 Jul 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; BRDT

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