NC-R17

CAT: 0804-HY-155075Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155075Size:1 Each
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Description
NC-R17 is a PROTAC-class, non-covalent GPX4 degrader based on RSL3, involved in ferroptosis. NC-R17 has antitumor activity and is used for non-covalent GPX4 PROTAC design[1]. NC-R17 consists of a target protein ligand (red part) Demethyl-RSL3 (HY-135832) ; an E3 ubiquitin ligase ligand (blue part) Lenalidomide (HY-A0003) and a PROTAC linker (black part) (HY-169376) . E3 ubiquitin ligase and linker can form Lenalidomide-C13-piperazine-Boc (HY-169377) [1][2].
CAS Number
[3049087-34-2]
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nc-r17.html
Solubility
10 mM in DMSO
Smiles
O=C(OC)[C@@H]1N(C(CC)=O)[C@@H](C2=CC=C(C(N3CCN(CCCCCCCCCCCCCNC4=C(CN(C5C(NC(CC5)=O)=O)C6=O)C6=CC=C4)CC3)=O)C=C2)C7=C(C(C=CC=C8)=C8N7)C1
Molecular Formula
C53H67N7O7
Molecular Weight
914.14
References & Citations
[1]Zheng C, et al. Structure-activity relationship study of RSL3-based GPX4 degraders and its potential noncovalent optimization. Eur J Med Chem. 2023 Jul 5;255:115393.|[2]Luo Y, et al. Ferroptosis in Cancer Therapy: Mechanisms, Small Molecule Inducers, and Novel Approaches. Drug Des Devel Ther. 2024 Jun 21;18:2485-2529.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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