NC-III-49-1

CAT: 0931-T74898-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T74898-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3031654-46-0

Target

Others, Epigenetic Reader Domain

Related Pathways

Others, Chromatin/Epigenetic

Bioactivity

NC-III-49-1 is a potent bivalent bromodomain and extraterminal domain (BET) inhibitor with significant affinity for various BRD4 and BRDT isoforms, as demonstrated by its Kd values of 0.095 nM for BRD4-1, 0.32 nM for BRD4-2, 0.29 nM for BRD4-T, 0.089 nM for BRDT-1, 5.5 nM for BRDT-2, and 0.058 nM for BRDT-T. Additionally, NC-III-49-1 exhibits antiproliferative effects and reduces the expression of c-Myc [1].

Smiles

CN(C1=O)C=C(C2=CC(NS(CC)(=O)=O)=CC=C2OCCOCCOCCOCCOC3=CC=C(NS(CC)(=O)=O)C=C3C(C4=C5C=CC=C4)=CN(C)C5=O)C6=C1C=CC=C6

Molecular Formula

C44H50N4O11S2

Molecular Weight

875.02

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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