NC-002

CAT: 0804-HY-P11311Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P11311Size:1 Each
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Description
NC-002, a cell-permeable peptide, is a Trypsin-like proteasome inhibitor without inhibition of lysosomal cysteine proteases. NC-002 is the epoxyketone derivative of Leupeptin (HY-18234) . NC-002 sensitizes myeloma cells to Bortezomib (HY-10227) and Carfilzomib (HY-10455) . NC-002 can be used for cancers research[1].
CAS Number
[1356828-46-0]
UNSPSC
12352209
Target
Proteasome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
CC(C)C[C@H](NC(C)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C([C@]1(CO1)C)=O)=O)=O
Molecular Formula
C23H42N6O5
Molecular Weight
482.62
References & Citations
[1]Mirabella AC, et al. Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chem Biol. 2011 May 27;18 (5) :608-18.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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