NC-002

• Description :

  NC-002, a cell-permeable peptide, is a Trypsin-like proteasome inhibitor without inhibition of lysosomal cysteine proteases. NC-002 is the epoxyketone derivative of Leupeptin (HY-18234) . NC-002 sensitizes myeloma cells to Bortezomib (HY-10227) and Carfilzomib (HY-10455) . NC-002 can be used for cancers research[1].

• UNSPSC :

  12352209

• Target :

  Proteasome

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Cancer

• Smiles :

  CC(C)C[C@H](NC(C)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C([C@]1(CO1)C)=O)=O)=O

• Molecular Formula :

  C23H42N6O5

• Molecular Weight :

  482.62

• References & Citations :

  [1]Mirabella AC, et al. Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chem Biol. 2011 May 27;18 (5) :608-18.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [1356828-46-0]