Trk-IN-20
CAT:
804-HY-150561
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Trk-IN-20
- CAS Number: 2460924-63-2
- UNSPSC Description: Trk-IN-20 is a kind of 3-vinylindazole derivatives. Trk-IN-20 suppresses Trk kinases functions by phosphorylation inhibition of TrkA/B/C with IC50 values of 1.6 nM, 2.9 nM and 2.0 nM, respectively[1].
- Target Antigen: Trk Receptor
- Type: Reference compound
- Related Pathways: Neuronal Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/trk-in-20.html
- Solubility: 10 mM in DMSO
- Smiles: FC1=CC([C@@H](C)NC2=CC3=C(C=C2)NN=C3/C=C/C4=NC=CC=C4)=CC(F)=C1
- Molecular Weight: 376.40
- References & Citations: [1]Duan Y, et al. Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors. Eur J Med Chem. 2020 Oct 1. 203:112552.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported