Trk-IN-20

CAT: 0804-HY-150561Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-150561Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Trk-IN-20 is a kind of 3-vinylindazole derivatives. Trk-IN-20 suppresses Trk kinases functions by phosphorylation inhibition of TrkA/B/C with IC50 values of 1.6 nM, 2.9 nM and 2.0 nM, respectively[1].
CAS Number
[2460924-63-2]
UNSPSC
12352005
Target
Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trk-in-20.html
Solubility
10 mM in DMSO
Smiles
FC1=CC([C@@H](C)NC2=CC3=C(C=C2)NN=C3/C=C/C4=NC=CC=C4)=CC(F)=C1
Molecular Formula
C22H18F2N4
Molecular Weight
376.40
References & Citations
[1]Duan Y, et al. Design, synthesis, and Structure-Activity Relationships (SAR) of 3-vinylindazole derivatives as new selective tropomyosin receptor kinases (Trk) inhibitors. Eur J Med Chem. 2020 Oct 1. 203:112552.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TrkA; TrkB; TrkC

Related Products

CatalogName
HY-146519TRK-IN-14
HY-144423Trk-IN-10
HY-12327Trk-IN-1
HY-146521TRK-IN-15
HY-144451TRK-IN-12
HY-160166TRK-IN-26
HY-160165TRK-IN-25
HY-146522TRK-IN-16
HY-144321-01Trk-IN-9
HY-146523TRK-IN-17

Alternative Products

CatalogName
MF-0140374-01Trk-IN-20
BAL5338Trk A Rabbit Polyclonal Antibody, 1 pack = 20 µL
PA1321-STrk-A
338192-01Trk A
BAL5128Trk B Rabbit Monoclonal Antibody, 1 pack = 20 µL
B8070-01Trk A Antibody
MBS3843734-01Trk-IN-4
MBS5821367TRK-IN-24
MBS5804784TRK-IN-19
MBS5806015TRK-IN-18

Popular Products