TRK-IN-12

TRK-IN-12

• CAS Number: 2823342-34-1
• UNSPSC Description: TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK (TRKG595R IC50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line (IC50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect (IC50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line[1].
• Target Antigen: Trk Receptor
• Type: Reference compound
• Related Pathways: Neuronal Signaling;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/trk-in-12.html
• Solubility: 10 mM in DMSO
• Smiles: CN1CC2=CC(F)=CC=C2OCCN(CC3=C4N=C1C=CN4N=C3)S(=O)(CCl)=O
• Molecular Weight: 439.89
• References & Citations: [1] Li P, et al. Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors [published correction appears in Bioorg Med Chem Lett. 2022 Jan 15;56:128502]. Bioorg Med Chem Lett. 2021;53:128409.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported