Trk-IN-10

• UNSPSC Description:

  Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK (IC50 = 0.86, 6.92 nM, against TrkA, TrkAG595R, respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase (Trk) is a key agent target in solid tumors. Trk-IN-10 (IC50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity[1].

• Target Antigen:

  Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trk-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@H]1CNC(C2=C3N=C4C(OC[C@H](N4CC5=CC=C(C=C5O1)F)C)=CN3N=C2)=O

• Molecular Weight:

  397.40

• References & Citations:

  [1]Fan Y, et al. Pyrizolo[1,5-a]pyrimidine derivatives of the second-generation TRK inhibitor: Design, synthesis and biological evaluation. Bioorg Med Chem Lett. 2022;63:128646.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2700265-61-6