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TRK-IN-29

CAT: 0931-T210169-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210169-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors
Bioactivity
TRK-IN-29 (Compound B31) is a second-generation TRK inhibitor with IC50 values of 9 nM for TRKAG595R, 0.6 nM for TRKAF589L, 18 nM for TRKAG667C, 5 nM for TRKA, and 6 nM for TRKC. It effectively inhibits the phosphorylation of TRKA and demonstrates significant antiproliferative activity against NTRK fusion-positive cells. TRK-IN-29 also exhibits excellent plasma stability and moderate pharmacokinetic properties.
Molecular Formula
C19H17F3N6O
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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