TRK-IN-32

• Target:

  Apoptosis|||Trk receptor

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Apoptosis

• Bioactivity:

  TRK-IN-32 is a potent TRK inhibitor. It significantly suppresses TRKWT, TRKG595R, and TRKG667C with IC50 values of 0.08 nM, 2.14 nM, and 0.68 nM, respectively. Additionally, TRK-IN-32 exhibits antiproliferative activity against various Ba/F3 cell lines transformed by wild-type, xDFG mutant, solvent front, and gatekeeper mutant TRK fusion proteins. It also induces apoptosis in Ba/F3-TRKAWT and Ba/F3-TRKAG667C cells. TRK-IN-32 is applicable in research on various cancers, including thyroid cancer and secretory breast cancer.

• Smiles:

  N([C@@H](C)C1=CC=C(F)C=N1)C2=NN3C(=CN=C3C=C2)C4=CC(=NN4)C5CC5

• Molecular Formula:

  C19H18FN7

• Molecular Weight:

  363.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3044124-79-7