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TRK-IN-32

CAT: 0931-T212244-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T212244-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3044124-79-7
Target
Apoptosis|||Trk receptor
Related Pathways
Tyrosine Kinase/Adaptors|||Apoptosis
Bioactivity
TRK-IN-32 is a potent TRK inhibitor. It significantly suppresses TRKWT, TRKG595R, and TRKG667C with IC50 values of 0.08 nM, 2.14 nM, and 0.68 nM, respectively. Additionally, TRK-IN-32 exhibits antiproliferative activity against various Ba/F3 cell lines transformed by wild-type, xDFG mutant, solvent front, and gatekeeper mutant TRK fusion proteins. It also induces apoptosis in Ba/F3-TRKAWT and Ba/F3-TRKAG667C cells. TRK-IN-32 is applicable in research on various cancers, including thyroid cancer and secretory breast cancer.
Smiles
N([C@@H](C)C1=CC=C(F)C=N1)C2=NN3C(=CN=C3C=C2)C4=CC(=NN4)C5CC5
Molecular Formula
C19H18FN7
Molecular Weight
363.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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