STAT3 degrader-2

STAT3 degrader-2

• CAS Number: 2497583-03-4
• UNSPSC Description: STAT3 degrader-2 is a PROTAC-based degrader of STAT3. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases[1]. STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
• Target Antigen: PROTACs; STAT
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;PROTAC;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/stat3-degrader-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1C[C@@H](C(N2[C@@](CC[C@H]2C(N[C@@H](CCC(N)=O)C(NC(C3=CC=CC=C3)C4=CC=CC=C4)=O)=O)([H])CC1)=O)NC(C5=CC6=CC(C(P(O)(O)=O)=O)=CC=C6N5)=O)CCCCCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7
• Molecular Weight: 1136.15
• References & Citations: [1]Shaomeng Wang, et al. Small molecule degraders of stat3. Patent. WO2020198435A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported