PROTAC STAT3 degrader-3

• UNSPSC Description:

  PROTAC STAT3 degrader-3 (S3D1) is a STAT3 PROTAC degrader with anticancer activity (Structural notes: (Blue: Cereblon ligand (HY-10984), Black: linker; Pink: Pentafluorobenzenesulfonamide(Me)-CH2-CONH-benzamide (HY-163526))[1].

• Target Antigen:

  PROTACs; STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;PROTAC;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-stat3-degrader-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(S(=O)(C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC(NC2=CC=C(C=C2)C(NCCOCCNC3=C4C(N(C(C4=CC=C3)=O)C5CCC(NC5=O)=O)=O)=O)=O

• Molecular Weight:

  780.68

• References & Citations:

  [1]Wang Kefeng, et al. STAT3 inhibitor, PROTAC molecule, and preparation methods and applications thereof. U.S, CN117720443, 2024-03-19.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported