PROTAC STAT3 degrader-3

PROTAC STAT3 degrader-3

• UNSPSC Description: PROTAC STAT3 degrader-3 (S3D1) is a STAT3 PROTAC degrader with anticancer activity (Structural notes: (Blue: Cereblon ligand (HY-10984), Black: linker; Pink: Pentafluorobenzenesulfonamide(Me)-CH2-CONH-benzamide (HY-163526))[1].
• Target Antigen: PROTACs; STAT
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;PROTAC;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-stat3-degrader-3.html
• Solubility: 10 mM in DMSO
• Smiles: CN(S(=O)(C1=C(C(F)=C(C(F)=C1F)F)F)=O)CC(NC2=CC=C(C=C2)C(NCCOCCNC3=C4C(N(C(C4=CC=C3)=O)C5CCC(NC5=O)=O)=O)=O)=O
• Molecular Weight: 780.68
• References & Citations: [1]Wang Kefeng, et al. STAT3 inhibitor, PROTAC molecule, and preparation methods and applications thereof. U.S, CN117720443, 2024-03-19.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported