TS-IN-2

• Description :

  TS-IN-2 (compound 17) is a thymidylate synthase (TS) inhibitor with an IC50 of 0.81 μM. TS-IN-2 induces cancer cell apoptosis and cell cycle arrest in S phase, and also inhibit DNA synthesis, resulting in DNA damage[1].

• UNSPSC :

  12352005

• Target :

  Thymidylate Synthase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ts-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  S=C1OC(COC2=CC=C(CC=C)C=C2OC)=NN1CN3CCOCC3

• Molecular Formula :

  C18H23N3O4S

• Molecular Weight :

  377.46

• References & Citations :

  [1]Syed Nazreen, et al. New Natural Eugenol Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Computational Studies. ACS Omega. 2023 May 15;8 (21) :18811-18822.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2945983-00-4]