TS-IN-2

• Description:

  TS-IN-2 (compound 17) is a thymidylate synthase (TS) inhibitor with an IC50 of 0.81 μM. TS-IN-2 induces cancer cell apoptosis and cell cycle arrest in S phase, and also inhibit DNA synthesis, resulting in DNA damage[1].

• UNSPSC:

  12352005

• Target:

  Thymidylate Synthase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ts-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  S=C1OC (COC2=CC=C (CC=C) C=C2OC) =NN1CN3CCOCC3

• Molecular Formula:

  C18H23N3O4S

• Molecular Weight:

  377.46

• References & Citations:

  [1]Syed Nazreen, et al. New Natural Eugenol Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Computational Studies. ACS Omega. 2023 May 15;8 (21) :18811-18822.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2945983-00-4