Ts-SA

CAT: 0804-HY-113658Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-113658Size:1 Each
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Description
Ts-SA is a carbonic anhydrase (CA) inhibitor with activity against seven human CA homologues. ts-SA can bind to the Zn (II) ion in the enzyme active site in a deprotonated form. The organic skeleton of ts-SA extends in the enzyme cavity and participates in multiple interactions with amino acid residues and water molecules. Due to its structural differences, the inhibitory performance of ts-SA is significantly better than that of another pyridine derivative. ts-SA exhibits low nanomolar inhibitory activity and is a multi-target CA inhibitor[1].
CAS Number
[100715-13-7]
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ts-sa.html
Smiles
O=S(NC(NC1=CC=C(C=C1)S(=O)(N)=O)=O)(C2=CC=C(C=C2)C)=O
Molecular Formula
C14H15N3O5S2
Molecular Weight
369.42
References & Citations
[1]Combining the tail and the ring approaches for obtaining potent and isoform-selective carbonic anhydrase inhibitors: solution and X-ray crystallographic studies
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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