TS-2

• Description:

  TS-2 is a fluorescent ligand of c-Myc G4 with anticancer activity. TS-2 inhibits the growth of cancer cells and induces apoptosis of cancer cells by targeting the c-MYC oncogene promoter G4, causing transcriptional repression of the c-Myc oncogene[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; c-Myc; G-quadruplex

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ts-2.html

• Concentration:

  10mM

• Purity:

  98.27

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C[N+]1=C(SC=C1)/C=C/C2=CC(C3=C4C=CC=C3)=C(C=C2)N4C5=CC=CC=C5.[I-]

• Molecular Formula:

  C24H19IN2S

• Molecular Weight:

  494.39

• References & Citations:

  [1]Rui Wang, et al. "Development of a fluorescent ligand that specifically binds to the c-MYC G-quadruplex by migrating the benzene group on a carbazole-benzothiazolium scaffold." Bioorganic Chemistry (2024) : 107690.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported