TS-IN-8

• Description:

  TS-IN-8 is a potent thymidylate synthase (TS) inhibitor. TS-IN-8 can induce apoptosis and cause cell cycle arrest at the G2/M in MCF-7 cells. TS-IN-8 can induce nuclear morphological changes. TS-IN-8 can increase intracellular reactive oxygen species (ROS) levels. TS-IN-8 can activate intrinsic apoptosis pathways by regulating apoptosis-related proteins such as the bax/bcl-2 ratio and caspase activation. TS-IN-8 can be used for the study of breast cancer[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bcl-2 Family; Caspase; Reactive Oxygen Species (ROS) ; Thymidylate Synthase

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Field of Research:

  Cancer

• Smiles:

  FC1=CC=C(C(N=C(SCCCCCC(OCC)=O)N2)=C(C#N)C2=O)C=C1

• Molecular Formula:

  C19H20FN3O3S

• Molecular Weight:

  389.44

• References & Citations:

  [1]Jaitak A, et al. Design, synthesis, anticancer evaluation, and In silico studies of 2-thiopyrimidine-5-carbonitrile derivatives as potent thymidylate synthase inhibitors. Eur J Med Chem. 2026 Jan 5;301:118205.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported