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TS-IN-8

CAT: 0804-HY-178911Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178911Size:1 Each
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Description
TS-IN-8 is a potent thymidylate synthase (TS) inhibitor. TS-IN-8 can induce apoptosis and cause cell cycle arrest at the G2/M in MCF-7 cells. TS-IN-8 can induce nuclear morphological changes. TS-IN-8 can increase intracellular reactive oxygen species (ROS) levels. TS-IN-8 can activate intrinsic apoptosis pathways by regulating apoptosis-related proteins such as the bax/bcl-2 ratio and caspase activation. TS-IN-8 can be used for the study of breast cancer[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; Reactive Oxygen Species (ROS) ; Thymidylate Synthase
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
FC1=CC=C(C(N=C(SCCCCCC(OCC)=O)N2)=C(C#N)C2=O)C=C1
Molecular Formula
C19H20FN3O3S
Molecular Weight
389.44
References & Citations
[1]Jaitak A, et al. Design, synthesis, anticancer evaluation, and In silico studies of 2-thiopyrimidine-5-carbonitrile derivatives as potent thymidylate synthase inhibitors. Eur J Med Chem. 2026 Jan 5;301:118205.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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