TS-IN-5

• Description:

  TS-IN-5 (Compound 15) is a thymidylate synthase (TS) inhibitor. TS-IN-5 induces Apoptosis by modulating Bax, BCL-2, PI3K, and STAT1 proteins. TS-IN-5 shows antitumor effects against liver, breast and colon cancers[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Bcl-2 Family; PI3K; STAT; Thymidylate Synthase

• Related Pathways:

  Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  O=C1C(C2=NC3=CC=CC=C3S2)=CNC(N4CCN(C)CC4)=N1

• Molecular Formula:

  C16H17N5OS

• Molecular Weight:

  327.40

• References & Citations:

  [1]Basiony EA, et al. Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents. Bioorg Chem. 2025 Jan;154:108066.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported