TS-24

• Description:

  TS-24 is an inhibitor for cathepsin S, with an IC50 of 4.3 μM. TS-24 exhibits radiosensitizing activity in wild type breast cancer susceptibility gene 1 (BRCA1) and in TNBC xenograft mice model, through induction of apoptosis[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Cathepsin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ts-24.html

• Concentration:

  10mM

• Purity:

  98.96

• Solubility:

  DMSO : ≥ 16.67 mg/mL

• Smiles:

  O=C(/C=C/C1=CN(C)C2=C1C=CC=C2)C3=CC4=CC=CC=C4O3

• Molecular Formula:

  C20H15NO2

• Molecular Weight:

  301.34

• References & Citations:

  [1]Choi E, et al., Radiosensitizing effect of a novel CTSS inhibitor by enhancing BRCA1 protein stability in triple-negative breast cancer cells. Cancer Sci. 2024 Apr 13.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Cathepsin S

• CAS Number:

  1563260-97-8