TS-IN-6

• Description:

  TS-IN-6 (Compound 10) is a thymidylate synthase (TS) inhibitor with an IC50 value of 0.54 μM, demonstrating significant antiproliferative activity. TS-IN-6 induces G1 phase cell cycle arrest and apoptosis (marked by substantial increases in both early and late apoptotic rates) and shows potential for research on cancers such as colon, breast, and liver cancers[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Thymidylate Synthase

• Related Pathways:

  Apoptosis

• Field of Research:

  Cancer

• Smiles:

  CC1=CC=CC=C1N2C(SCC3=CN(C4=CC=C(F)C=C4F)N=N3)=NN=C2COC5=CC=C6C=CC=CC6=C5

• Molecular Formula:

  C29H22F2N6OS

• Molecular Weight:

  540.59

• References & Citations:

  [1]Alam, M. M., et al. New Triazole Hybrids as Anticancer Agents Targeting Thymidylate Synthase: Synthesis, Biological and Molecular Docking Studies. Polycyclic Aromatic Compounds, 1–16.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported