Multi-kinase-IN-5

• UNSPSC Description:

  Multi-kinase-IN-5 (compound 15c) is a promising multi-kinase inhibitory agent. Multi-kinase-IN-5 inhibits a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDGFR and BRAF), showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC50 of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively[1].

• Target Antigen:

  c-Kit; c-Met/HGFR; FGFR; PDGFR; Raf; RET; VEGFR

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/multi-kinase-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1NC2=CC=CC=C2/C1=C/NC3=CC=C(NC(NC4=NC=CS4)=O)C=C3

• Molecular Weight:

  377.42

• References & Citations:

  [1]Ismail RSM, et al. Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents. BMC Chem. 2023 Jul 18;17(1):81.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported