Multi-kinase-IN-5

Multi-kinase-IN-5

• UNSPSC Description: Multi-kinase-IN-5 (compound 15c) is a promising multi-kinase inhibitory agent. Multi-kinase-IN-5 inhibits a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDGFR and BRAF), showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC50 of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively[1].
• Target Antigen: c-Kit; c-Met/HGFR; FGFR; PDGFR; Raf; RET; VEGFR
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/multi-kinase-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1NC2=CC=CC=C2/C1=C/NC3=CC=C(NC(NC4=NC=CS4)=O)C=C3
• Molecular Weight: 377.42
• References & Citations: [1]Ismail RSM, et al. Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents. BMC Chem. 2023 Jul 18;17(1):81.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported