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Multi-kinase-IN-5

CAT: 0804-HY-149415Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149415Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Multi-kinase-IN-5 (compound 15c) is a promising multi-kinase inhibitory agent. Multi-kinase-IN-5 inhibits a panel of protein kinases (RET, KIT, cMet, VEGFR1,2, FGFR1, PDGFR and BRAF), showing % inhibition of 74%, 31%, 62%, 40%, 73%, 74%, 59%, and 69%, respectively, and IC50 of 1.287, 0.117 and 1.185 μM against FGFR1, VEGFR, and RET kinases, respectively[1].
UNSPSC
12352005
Target
C-Kit; c-Met/HGFR; FGFR; PDGFR; Raf; RET; VEGFR
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/multi-kinase-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=CC=CC=C2/C1=C/NC3=CC=C(NC(NC4=NC=CS4)=O)C=C3
Molecular Formula
C19H15N5O2S
Molecular Weight
377.42
References & Citations
[1]Ismail RSM, et al. Discovery of a new potent oxindole multi-kinase inhibitor among a series of designed 3-alkenyl-oxindoles with ancillary carbonic anhydrase inhibitory activity as antiproliferative agents. BMC Chem. 2023 Jul 18;17 (1) :81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; PDGFR; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1

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