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Multi-kinase-IN-6

CAT: 0804-HY-156470Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-156470Size:1 Each
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Description
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect[1].
CAS Number
3009081-73-3
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; Apoptosis; Casein Kinase; CDK; Checkpoint Kinase (Chk) ; c-Kit; EGFR; Pim; Trk Receptor
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Neuronal Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/multi-kinase-in-6.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1)=CC=C1C2=CC=NC3=C(C4=NOC(C)=N4)C(C)=NN32
Molecular Formula
C17H15N5O2
Molecular Weight
321.33
References & Citations
[1]Mustafa A. Al-Qadhi, et al. Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo{1,5-a}Pyrimidines as multikinase inhibitors. European Journal of Medicinal Chemistry. Volume 262, 15 December 2023, 115918.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; Chk1; CK2; EGFR/ErbB1/HER1; PIM1; TrkA

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