Multi-kinase-IN-6

Multi-kinase-IN-6

• CAS Number: 3009081-73-3
• UNSPSC Description: Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect[1].
• Target Antigen: Anaplastic lymphoma kinase (ALK); Apoptosis; Casein Kinase; CDK; Checkpoint Kinase (Chk); c-Kit; EGFR; Pim; Trk Receptor
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;JAK/STAT Signaling;Neuronal Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/multi-kinase-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: COC(C=C1)=CC=C1C2=CC=NC3=C(C4=NOC(C)=N4)C(C)=NN32
• Molecular Weight: 321.33
• References & Citations: [1]Mustafa A. Al-Qadhi, et al. Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo{1,5-a}Pyrimidines as multikinase inhibitors. European Journal of Medicinal Chemistry. Volume 262, 15 December 2023, 115918.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported