Multi-kinase-IN-6

• UNSPSC Description:

  Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that shows good enzyme inhibitory activity against TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2. Multi-kinase-IN-6 reveals antiproliferative activity against MCF7, HCT116 and EKVX with IC50 values of 3.36 μM, 1.40 μM and 3.49 μM, respectively. Multi-kinase-IN-6 shows cell cycle arrest at the G1/S phase and G1 phase in MCF7 and HCT116 cells with good apoptotic effect[1].

• Target Antigen:

  Anaplastic lymphoma kinase (ALK); Apoptosis; Casein Kinase; CDK; Checkpoint Kinase (Chk); c-Kit; EGFR; Pim; Trk Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;JAK/STAT Signaling;Neuronal Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/multi-kinase-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC(C=C1)=CC=C1C2=CC=NC3=C(C4=NOC(C)=N4)C(C)=NN32

• Molecular Weight:

  321.33

• References & Citations:

  [1]Mustafa A. Al-Qadhi, et al. Design and synthesis of certain 7-Aryl-2-Methyl-3-Substituted Pyrazolo{1,5-a}Pyrimidines as multikinase inhibitors. European Journal of Medicinal Chemistry. Volume 262, 15 December 2023, 115918.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3009081-73-3