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Multi-target kinase-IN-5

CAT: 0804-HY-174128Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174128Size:1 Each
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Description
Multi-target kinase-IN-5 (Compound 23) is an orally active ERK1/2 inhibitor (IC50 values are 3.04 nM and 1.57 nM, respectively) . Multi-target kinase-IN-5 significantly inhibits cancer cell proliferation, migration and invasion, and induces cell apoptosis and cell cycle arrest. Multi-target kinase-IN-5 inhibits the phosphorylation of ERK1/2 and downregulates the activity of its downstream substrate RSK to exert anti-tumor effects. Multi-target kinase-IN-5 can be used in cancer research[1].
UNSPSC
12352005
Target
Apoptosis; ERK
Related Pathways
Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=CC2=C(C=C1)C=NC(NC3COC3)=N2)N[C@H](CO)C4=CC=C(C(F)=C4)Cl
Molecular Formula
C20H18ClFN4O3
Molecular Weight
416.83
References & Citations
[1]Zhang P, et al. Discovery of 2-Amino-7-Amide Quinazoline Derivatives as Potent and Orally Bioavailable Inhibitors Targeting Extracellular Signal-Regulated Kinase 1/2. J Med Chem. 2025 Jun 12;68 (11) :12204-12228.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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