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Multi-kinase-IN-2

CAT: 0931-T63967-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63967-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2095628-21-8
Target
Others, Apoptosis, FGFR, VEGFR, Akt, PDGFR, c-Kit, Src
Related Pathways
Apoptosis, Angiogenesis, Others, Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling
Bioactivity
Multi-kinase-IN-2 is an orally active inhibitor of angiokinases. multi-kinase-IN-2 significantly inhibits the activity of angiokinases such as VEGFR-1/2/3, PDGFRα/β, FGFR-1, LYN and c-KIT kinases. -IN-2 significantly attenuates phosphorylation of AKT and ERK proteins, induces apoptosis and has anticancer effects.
Smiles
C(\NC1=CC=C(C=C1)N2C(CN3CCN(C)CC3)=CC=C2C)(=C\4/C=5C(NC4=O)=CC(C(OC)=O)=CC5)/C6=CC=CC=C6
Molecular Formula
C34H35N5O3
Molecular Weight
561.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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