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Multi-kinase-IN-8

CAT: 0804-HY-179439Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179439Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Multi-kinase-IN-8 is a muti-kinase inhibitor. Multi-kinase-IN-8 inhibits COX-1 (IC50 of 12.6 μM), COX-2 (IC50 of 0.05 μM) and VEGFR-2 (IC50 of 0.12 nM) . Multi-kinase-IN-8 inhibits tumor-associated carbonic anhydrases (CA IX and CA XII with Ki of 31.5 nM and 386.9 nM, respectively) . Multi-kinase-IN-8 triggers cell cycle arrest and apoptosis through upregulation of Caspase 9 and Bax along with downregulation of Bcl 2. Multi-kinase-IN-8 suppresses PGE2, p-VEGFR-2, MMP-9 and HIF-1α and exhibits growth-inhibitory activity against breast cancer, lung cancer, and colorectal adenocarcinoma[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; COX; HIF/HIF Prolyl-Hydroxylase; MMP; VEGFR
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=S(C1=CC=C(N2N=NC(COC3=CC=C(/C=N/N=C4C(NC5=C\4C=C(OC)C=C5)=O)C=C3)=C2)C=C1)(N)=O
Molecular Formula
C25H21N7O5S
Molecular Weight
531.54
References & Citations
[1]El-Attar MAZ, et.al. Click-modifiable isatin hydrazones as COX-2, VEGFR-2, and carbonic anhydrase inhibitors: A multi-target approach to cancer therapy. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118304.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2; VEGFR2/KDR/Flk-1

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