Multi-kinase-IN-4

• Target:

  EGFR|||Apoptosis|||Necroptosis|||VEGFR|||CDK

• Related Pathways:

  Cell Cycle/Checkpoint|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis|||Apoptosis

• Bioactivity:

  Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor effective against VEGFR2, EGFR, HER2, and CDK2, with IC50 values of 0.33, 0.22, 0.18, and 2.09 ?M, respectively. It shows broad-spectrum anti-cancer activity in HepG2, MCF-7, MDA-231, and HeLa cell lines (IC50: 1.94–7.1 µM) and exhibits lower toxicity in WI-38 cells (IC50 = 40.85 µM) . Additionally, it induces apoptosis, causes S-phase cell cycle arrest in HepG2 cells, and holds potential for cancer research [1].

• Molecular Formula:

  C21H20ClFN2OS

• Molecular Weight:

  402.91

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C