Multi-kinase-IN-4

CAT: 0931-MF-0156849-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0156849-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
EGFR|||Apoptosis|||Necroptosis|||VEGFR|||CDK
Related Pathways
Cell Cycle/Checkpoint|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling|||Angiogenesis|||Apoptosis
Bioactivity
Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor effective against VEGFR2, EGFR, HER2, and CDK2, with IC50 values of 0.33, 0.22, 0.18, and 2.09 ?M, respectively. It shows broad-spectrum anti-cancer activity in HepG2, MCF-7, MDA-231, and HeLa cell lines (IC50: 1.94–7.1 µM) and exhibits lower toxicity in WI-38 cells (IC50 = 40.85 µM) . Additionally, it induces apoptosis, causes S-phase cell cycle arrest in HepG2 cells, and holds potential for cancer research [1].
Molecular Formula
C21H20ClFN2OS
Molecular Weight
402.91
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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MBS5820454Multi-kinase-IN-4
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