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Multi-kinase-IN-4

CAT: 0931-T78792-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T78792-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
EGFR, Apoptosis, Necroptosis, VEGFR, CDK
Related Pathways
Cell Cycle/Checkpoint, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Apoptosis
Bioactivity
Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor effective against VEGFR2, EGFR, HER2, and CDK2, with IC50 values of 0.33, 0.22, 0.18, and 2.09 μM, respectively. It shows broad-spectrum anti-cancer activity in HepG2, MCF-7, MDA-231, and HeLa cell lines (IC50: 1.94–7.1 μM) and exhibits lower toxicity in WI-38 cells (IC50 = 40.85 μM) . Additionally, it induces apoptosis, causes S-phase cell cycle arrest in HepG2 cells, and holds potential for cancer research [1].
Molecular Formula
C21H20ClFN2OS
Molecular Weight
402.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

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GTR19230922-01Multi-kinase-IN-4
HY-168115Multi-kinase inhibitor 4
GTR19275114-01Multi kinase ligand 4
HY-172771Multi-target kinase inhibitor 4
HY-150026Multi-kinase-IN-2
HY-150027Multi-kinase-IN-3
MBS5823392Multi-kinase-IN-6
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HY-178142Multi-kinase-IN-7

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