Multi-kinase-IN-5

• Target:

  Others|||c-Kit|||PDGFR|||FGFR|||VEGFR|||c-RET|||c-Met/HGFR|||Raf

• Related Pathways:

  MAPK|||Tyrosine Kinase/Adaptors|||Others|||Angiogenesis|||Apoptosis

• Bioactivity:

  Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that demonstrates significant inhibition of a range of protein kinases, including RET (69%), KIT (31%), cMet (62%), VEGFR1 (40%), VEGFR2 (73%), FGFR1 (74%), PDGFR (59%), and BRAF (74%) . Its IC50 values are 1.287 ?M for FGFR1, 0.117 ?M for VEGFR, and 1.185 ?M for RET kinases, indicating its potency [1].

• Molecular Formula:

  C19H15N5O2S

• Molecular Weight:

  377.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C