Multi-kinase-IN-2

• UNSPSC Description:

  Multi-kinase-IN-2 (compound 7h) is an orally active and potent angiokinase inhibitor. Multi-kinase-IN-2 exhibits excellent inhibitory activity against angiokinases including VEGFR-1/2/3, PDGFRα/β, and FGFR-1, as well as LYN and c-KIT kinases. Multi-kinase-IN-2 significantly attenuates phosphorylation of AKT and ERK proteins. Multi-kinase-IN-2 induces cell apoptosis. Multi-kinase-IN-2 shows anticancer activity[1].

• Target Antigen:

  Akt; Apoptosis; c-Kit; FGFR; PDGFR; Src; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/multi-kinase-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(NC3=CC=C(N4C(C)=CC=C4CN5CCN(C)CC5)C=C3)/C6=CC=CC=C6)OC

• Molecular Weight:

  561.67

• References & Citations:

  [1]Qin M, et al. Structural modifications of indolinones bearing a pyrrole moiety and discovery of a multi-kinase inhibitor with potent antitumor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115486.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2095628-21-8