BChE-IN-8

• UNSPSC Description:

  BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research[1].

• Target Antigen:

  Amyloid-β

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bche-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC(C#N)=CC(Br)=C1)CN2C3=CC=CC=C3N=C2C4=NON=C4N

• Molecular Weight:

  438.24

• References & Citations:

  [1]Li Q, Xiong B, Wang Y, Lyu W, Xing S, Chen Y, Liao Q, He S, Feng F, Liu W, Chen Y, Sun H. A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement. Eur J Med Chem. 2022 Jun 7;239:114510.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2653349-78-9