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BChE-IN-17

CAT: 0804-HY-155140-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155140-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BChE-IN-17 (compound 6n) is a potent and selective BChE inhibitor with IC50s of 10.5 nM and 32.5 nM for eqBChE and hBChE, respectively. BChE-IN-17 shows over 1000-fold selectivity to BChE against AChE. BChE-IN-17 shows low neurotoxicity and moderate neuroprotective effects[1].
CAS Number
2425632-57-9
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bche-in-17.html
Purity
99.07
Solubility
DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
BrC1=CC(CN2CC(SC(NS(C3=CC=C(C)C=C3)(=O)=O)=C4C(OC)=O)=C4CC2)=CC=C1
Molecular Formula
C23H23BrN2O4S2
Molecular Weight
535.47
References & Citations
[1]Tingkai Chen, et al. The structural modification and biological evaluation of tetrahydrothienopyridine derivatives as selective BChE inhibitors. Bioorg Med Chem Lett. 2023 Sep 1;93:129436.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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