BChE-IN-22

• Description:

  BChE-IN-22 (compound 5A) is a selective eqBChE inhibitor (IC50: 0.53 μM), has anti-inflammatory and neuroprotective activities. BChE-IN-22 can inhibit cell damage caused by Aβ25-35 (HY-P0128) and improve cognitive dysfunction caused by Scopolamine (HY-N0296) [1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bche-in-22.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN(C(OC1=CC(OC(N(C)C)=O)=C(C=C1)C(N2CCC(CC2)CC3=CC=CC=C3)=O)=O)C

• Molecular Formula:

  C25H31N3O5

• Molecular Weight:

  453.53

• References & Citations:

  [1]Zhou Y, et al. Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2231661.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BChE