BChE-IN-19

• Description:

  BChE-IN-19 (Compound 7b) is a para-substituted derivative of indone (7b) with inhibitory activity of butyryl cholinesterase (BChE) (IC50=0.04 μM) . BChE-IN-19 improves cholinergic scheduling in the nervous system. BChE-IN-19 can be used against Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bche-in-19.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C (CC2=CC=C (OCCCN3CCOCC3) C=C2) CC4=C1C=C (OC) C (OC) =C4

• Molecular Formula:

  C25H31NO5

• Molecular Weight:

  425.52

• References & Citations:

  [1]Etemadi A, et al. Design, Synthesis, and Biological Evaluation of Novel Indanone Derivatives as Cholinesterase Inhibitors for Potential Use in Alzheimer's Disease. Chem Biodivers. 2023 Aug;20 (8) :e202300075.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BChE