BChE-IN-44

• Description:

  BChE-IN-44 is a potent, brain-penetrant, highly selective BChE inhibitor [equine BChE IC50 = 18.00 pM, human BChE IC50 = 1.50 nM]. BChE-IN-44 shows neuroprotective effects against the Aβ1-42-induced injury model and inhibitory effects on Aβ1-42 self-aggregation. BChE-IN-44 reduces the levels of inflammatory factors (NO, IL-6, and TNF-α) in Lipopolysaccharides (HY-D1056) -induced BV2 cells. BChE-IN-44 can significantly ameliorate Scopolamine (HY-N0296) -induced cognition impairment. BChE-IN-44 exhibits capacity in the regulation of BChE and acetylcholine levels in the mouse hippocampus. BChE-IN-44 can be used for the study of Alzheimer’s disease (AD) [1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE) ; Interleukin Related; nAChR; TNF Receptor

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  CC1=CC(O)=C(C=C1)C(NCCC2=CNC3=CC=C(C=C23)OC(N4CCC4)=O)=O

• Molecular Formula:

  C22H23N3O4

• Molecular Weight:

  393.44

• References & Citations:

  [1]Zhao Y, et al. Discovery of a highly selective BChE inhibitor with concomitant anti-neuroinflammatory activity for treating Alzheimer's disease. Eur J Med Chem. 2025 Dec 5;299:118071.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BChE; IL-6