BChE-IN-46

CAT: 0804-HY-179363Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179363Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BChE-IN-46 is a selective and brain-penetrant BChE inhibitor (eqBChE IC50 = 7.44 x 10−5 μM, SI > 270,000; hBChE, IC50 = 1.48 x 10−3 μM) . BChE-IN-46 has COX-2 inhibitory activity (IC50 = 0.11 μM) . BChE-IN-46 exhibits neuroprotective effects, enhances acetylcholine levels, and alleviates cognitive deficits, anxiety, and learning/memory impairments. BChE-IN-46 can be used for the development of anti-Alzheimer's disease drugs[1].
UNSPSC
12352005
Target
Cholinesterase (ChE) ; COX
Related Pathways
Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC(C=C1)=CC(OC(N2CCC2)=O)=C1C(NCCC3=CNC4=CC(N(C)C)=CC=C43)=O
Molecular Formula
C24H28N4O3
Molecular Weight
420.50
References & Citations
[1]Wu K. et al. Design of N-salicyltryptamines-based highly selective BChE inhibitors to elevate brain acetylcholine, improve learning, and reduce amyloid-β in Alzheimer's disease. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118273.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE; COX-2

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