BChE-IN-39

• Target:

  Cholinesterase (ChE)

• Related Pathways:

  Neuroscience

• Bioactivity:

  BChE-IN-39 (Compound 7c) selectively inhibits butyrylcholinesterase (BChE) with an IC50 of 0.08 ?M, while showing an IC50 of 3.98 ?M for acetylcholinesterase (AChE) inhibition. Additionally, BChE-IN-39 downregulates GSK-3? expression, thereby inhibiting the excessive phosphorylation of tau protein.

• Smiles:

  C1=CC=C2C(=C1)C(=O)N(C2=O)CC3=CC=C(C=C3)C(=O)NCC4=C[N+](=CC=C4)CC5=CC(=CC=C5)F.[Cl-]

• Molecular Formula:

  C29H23ClFN3O3

• Molecular Weight:

  515.963

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C