BChE-IN-41

• Description :

  BChE-IN-41 is a highly selective Butyrylcholinesterase (BChE) inhibitor (IC50 =12 nM, Ki = 6.6 nM) . BChE-IN-41 has high brain penetration with a brain-to-plasma ratio of 9.0. BChE-IN-41 has pro-cognitive effects on mice with AD-like symptoms induced by Scopolamine (HY-N0296) and Aβ1-42[1].

• UNSPSC :

  12352005

• Target :

  Amyloid-β; Cholinesterase (ChE) ; Tau Protein

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  CN(S(=O)(C1=CC=C(C=CC=C2)C2=C1)=O)C[C@@H](C3)CCN3CC4=CC=CC=C4

• Molecular Formula :

  C23H26N2O2S

• Molecular Weight :

  394.53

• References & Citations :

  [1]Urban Košak, et al. Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease. J Med Chem. 2025 Jun 12. 68 (11) : 11693-11723.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  AChE