BChE-IN-41

CAT: 0804-HY-174381Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174381Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BChE-IN-41 is a highly selective Butyrylcholinesterase (BChE) inhibitor (IC50 =12 nM, Ki = 6.6 nM) . BChE-IN-41 has high brain penetration with a brain-to-plasma ratio of 9.0. BChE-IN-41 has pro-cognitive effects on mice with AD-like symptoms induced by Scopolamine (HY-N0296) and Aβ1-42[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Tau Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CN(S(=O)(C1=CC=C(C=CC=C2)C2=C1)=O)C[C@@H](C3)CCN3CC4=CC=CC=C4
Molecular Formula
C23H26N2O2S
Molecular Weight
394.53
References & Citations
[1]Urban Košak, et al. Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease. J Med Chem. 2025 Jun 12. 68 (11) : 11693-11723.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE

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