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BACE1-IN-12

CAT: 0804-HY-147851Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147851Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BACE1-IN-12 (compound 7g) is a potent and BBB-penetrated BACE1 inhibitor, with an IC50 of 8.9 µM. BACE1-IN-12 shows selective BuChE (butyrylcholinesterase) inhibitory activity with an IC50 of 3.2 µM. BACE1-IN-12 shows effective antioxidant effect with an IC50 of 10.2 μM (DPPH) . BACE1-IN-12 might be served as a potential anti-Alzheimer agent[1].
CAS Number
2479315-19-8
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-in-12.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(CN2N=NC(COC3=CC=C(C4=C(NC5CCCCC5)N6C=CC=CC6=N4)C=C3)=C2)C=C1Cl
Molecular Formula
C29H28Cl2N6O
Molecular Weight
547.48
References & Citations
[1]Haghighijoo Z, et al. N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer's disease. Bioorg Chem. 2020 Oct;103:104146.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1

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