BACE1-IN-15

• Description:

  BACE1-IN-15 (Compound 72) is a selective inhibitor of beta-site amyloid precursor protein cleaving enzyme 1 (BACE-1) with oral activity and the ability to penetrate the blood-brain barrier. Its IC50 value is 121.65 nM (the IC50 value for BACE-2 is 480.92 nM) . BACE1-IN-15 can be used in the research of the Alzheimer's disease field[1]

• UNSPSC:

  12352005

• Target:

  Beta-secretase

• Related Pathways:

  Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  FC1=C(C(NC2=CC(SC(N)=N3)=C3C=C2)=O)C=CC(F)=C1OC

• Molecular Formula:

  C15H11F2N3O2S

• Molecular Weight:

  335.33

• References & Citations:

  [1]Afzal O, et al. Rational design, docking, simulation, synthesis, and in vitro studies of small benzothiazole molecules as selective BACE1 inhibitors. J Biomol Struct Dyn. 2025 Mar 2:1-12.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported