BACE1-IN-1

• Description :

  BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2, respectively.

• UNSPSC :

  12352005

• Target :

  Beta-secretase

• Type :

  Reference compound

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/BACE1-IN-1.html

• Purity :

  98.72

• Solubility :

  DMSO : 85 mg/mL (ultrasonic)

• Smiles :

  O=C(C1=NC=C(C#N)C=C1)NC2=CC=C(F)C([C@@]3(C)N=C(N)OCC3(F)F)=C2

• Molecular Formula :

  C18H14F3N5O2

• Molecular Weight :

  389.33

• References & Citations :

  [1]Hilpert H, et al. β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease. J Med Chem. 2013 May 23;56 (10) :3980-95.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  BACE1

• CAS Number :

  [1310347-50-2]