BACE1-IN-6

CAT: 0804-HY-145345Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-145345Size:1 Each
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Description
BACE1-IN-6 is a BACE1 inhibitor with an IC50 value of 1.5 nM.
CAS Number
[2079945-75-6]
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCOCC1)[C@@]23[C@@]([C@](N=C(S3)N)(C4=CC(/C=C(C5=CC=C(C=N5)C#N)\F)=CC=C4F)C)([H])C2
Molecular Formula
C25H23F2N5O2S
Molecular Weight
495.54
References & Citations
[1]Frohn M, et al. The development of a structurally distinct series of BACE1 inhibitors via the (Z) -fluoro-olefin amide bioisosteric replacement. Bioorg Med Chem Lett. 2020 Jul 15;30 (14) :127240.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1

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