BACE1-IN-4

• Description:

  BACE1-IN-4 is a potent and highly selective BACE1 inhibitor, with an IC50 of 3.8 nM and a Ki of 1.9 nM, more selective at BACE1 over BACE2. Anti-Alzheimer’s disease[1].

• UNSPSC:

  12352005

• Target:

  Beta-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bace1-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=N[C@@](C2=CC(NC(C3=NC=C(OCF)N=C3)=O)=CC=C2F)(C)C4(CCS(CC4)(=O)=O)CS1

• Molecular Formula:

  C21H23F2N5O4S2

• Molecular Weight:

  511.57

• References & Citations:

  [1]Fujimoto K, et al. Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2. J Med Chem. 2019 May 23;62 (10) :5080-5095.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BACE1

• CAS Number:

  [2361157-92-6]