BACE1-IN-9

CAT: 0804-HY-144741Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144741Size:1 Each
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Description
BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC50 of 1.2 µM[1].
CAS Number
[2872604-91-4]
UNSPSC
12352005
Target
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bace1-in-9.html
Solubility
10 mM in DMSO
Smiles
CCC[C@@H]1NC([C@H](C(C)(OC/C=C\C[C@H](NC1=O)[C@@H](CNC2=CC=C(C=C2)CC(O)=O)O)C)NC([C@H](CCC(O)=O)N)=O)=O
Molecular Formula
C30H45N5O9
Molecular Weight
619.71
References & Citations
[1]Otani T, Hattori Y, Akaji K, Kobayashi K. Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure. Bioorg Med Chem. 2021 Dec 15;52:116517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1

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