BACE1-IN-9

• Description:

  BACE1-IN-9 (compound 82b) is a potent BACE1 (β-site APP cleaving enzyme 1) inhibitor, with an IC50 of 1.2 µM[1].

• UNSPSC:

  12352005

• Target:

  Beta-secretase

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/bace1-in-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC[C@@H]1NC([C@H](C(C)(OC/C=C\C[C@H](NC1=O)[C@@H](CNC2=CC=C(C=C2)CC(O)=O)O)C)NC([C@H](CCC(O)=O)N)=O)=O

• Molecular Formula:

  C30H45N5O9

• Molecular Weight:

  619.71

• References & Citations:

  [1]Otani T, Hattori Y, Akaji K, Kobayashi K. Macrocyclic BACE1 inhibitors with hydrophobic cross-linked structures: Optimization of ring size and ring structure. Bioorg Med Chem. 2021 Dec 15;52:116517.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  BACE1

• CAS Number:

  [2872604-91-4]