NF-κB-IN-5

• UNSPSC Description:

  NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1].

• Target Antigen:

  Apoptosis; NF-κB

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nf-κb-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N/N=C/C1=C/CC[C@]2(C)[C@@]([C@@]([C@](CC1)([H])C3=C)([H])OC3=O)([H])O2)NC4=CC=C(C)C=C4

• Molecular Weight:

  409.48

• References & Citations:

  [1]Jia X, et al. Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones. Bioorg Med Chem. 2020 Jul 1;28(13):115557.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2425675-52-9