NF-κB-IN-5

NF-κB-IN-5

• CAS Number: 2425675-52-9
• UNSPSC Description: NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1].
• Target Antigen: Apoptosis; NF-κB
• Type: Reference compound
• Related Pathways: Apoptosis;NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nf-κb-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N/N=C/C1=C/CC[C@]2(C)[C@@]([C@@]([C@](CC1)([H])C3=C)([H])OC3=O)([H])O2)NC4=CC=C(C)C=C4
• Molecular Weight: 409.48
• References & Citations: [1]Jia X, et al. Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones. Bioorg Med Chem. 2020 Jul 1;28(13):115557.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported