RegisterLogin

NF-κB-IN-5

CAT: 0804-HY-147682Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147682Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
NF-κB-IN-5 (compound 4d) is an orally active and potent NF-κB inhibitor by interacting directly with NF-κB. NF-κB-IN-5 shows antitumor activity against human cancer cell lines (HCT116, U87-MG, HepG2, BGC823, PC9), with IC50 values of 5.35, 2.81, 2.83, 2.02 and 3.90 μM, respectively. NF-κB-IN-5 induces apoptosis in U87-MG tumor cell and cell cycle arrest in G0/G1 phase[1].
CAS Number
[2425675-52-9]
UNSPSC
12352005
Target
Apoptosis; NF-κB
Type
Reference compound
Related Pathways
Apoptosis; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nf-κb-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C(N/N=C/C1=C/CC[C@]2(C)[C@@]([C@@]([C@](CC1)([H])C3=C)([H])OC3=O)([H])O2)NC4=CC=C(C)C=C4
Molecular Formula
C23H27N3O4
Molecular Weight
409.48
References & Citations
[1]Jia X, et al. Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones. Bioorg Med Chem. 2020 Jul 1;28 (13) :115557.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-126026NF-κB-IN-17
HY-162004NF-κB-IN-14
HY-149580NF-κB-IN-12
HY-147770NF-κB-IN-6
HY-138537-01NF-κB-IN-1
HY-149248NF-κB-IN-8
HY-175833NF-κB-IN-20
HY-158156NF-κB-IN-16
HY-149838NF-κB-IN-9
HY-144744NF-κB-IN-3

Alternative Products

CatalogName
T62060-01NF-?B-IN-5
sc-515045NFκB p65 (E-5)
sc-7386NFκB p52 (C-5)
sc-7386 XNFκB p52 (C-5) X
sc-7386 FITCNFκB p52 (C-5) FITC
sc-515045 XNFκB p65 (E-5) X
sc-7386 ACNFκB p52 (C-5) AC
sc-7386 PENFκB p52 (C-5) PE
sc-7386 HRPNFκB p52 (C-5) HRP
60614NF-κB Reporter Kit (NF-κB Signaling Pathway)

Popular Products