STAT3-IN-10

• Description :

  STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 μM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis[1].

• CAS Number :

  [2499491-04-0]

• UNSPSC :

  12352005

• Target :

  Apoptosis; STAT

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/stat3-in-10.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC(C=C1)=CC=C1NC2=CC(C3=C(C2=O)OC(C(C)=O)=C3)=O

• Molecular Formula :

  C17H13NO5

• Molecular Weight :

  311.29

• References & Citations :

  [1]Kai-Rui Feng, et al. Design, synthesis and biological evaluation of novel potent STAT3 inhibitors based on BBI608 for cancer therapy. Eur J Med Chem. 2020 Sep 1;201:112428.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  STAT3