Antitumor agent-60

• UNSPSC Description:

  Antitumor agent-60 (compound 20) is a potent antitumor agent, targeting RAS-RAF signaling pathway and binding to CRAF with a Kd value of 3.93 μM. Antitumor agent-60 induces apoptosis by blocking cell cycle at G2/M phase. Antitumor agent-60 enhances the level of p53 and ROS. Antitumor agent-60 causes oval and irregular nucleus in cancer cells. Antitumor agent-60 can suppress the growth of tumor to some extent in A549 xenograft model[1].

• Target Antigen:

  Apoptosis; MDM-2/p53; Raf; Ras; ROS Kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;GPCR/G Protein;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-60.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC(OC)=C(C(OC)=C1)/C=C/S(=O)(CC2=CC=C(C(OC(CCCC(O)=O)=O)=C2)OC)=O

• Molecular Weight:

  508.54

• References & Citations:

  [1]Liu Z, et al. Targeting RAS-RAF pathway significantly improves antitumor activity of Rigosertib-derived platinum(IV) complexes and overcomes cisplatin resistance. Eur J Med Chem. 2020;194:112269.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4