Antitumor agent-58

• UNSPSC Description:

  Antitumor agent-58 (Compound C18) is an anti-tumor agent. Antitumor agent-58 effectively inhibits colony formation and cell migration of MGC-803 cells. Antitumor agent-58 induces apoptosis of MGC-803 cells through activation of the p38 and JNK signaling pathways. Antitumor agent-58 induces mitochondrial dysfunction of MGC-803 cells. Antitumor agent-58 effectively inhibits tumor growth of xenograft model bearing MGC-803 cells[1].

• Target Antigen:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-58.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=NC2=NC(SCC3=CC=C(C=C3)C(F)(F)F)=NN2C(N4CC[C@H]([C@H](C4)N(C5=NC=NC6=C5C=CN6)C)C)=C1

• Molecular Weight:

  567.63

• References & Citations:

  [1]Shi XJ, et al. Discovery of tofacitinib derivatives as orally active antitumor agents based on the scaffold hybridization strategy. Eur J Med Chem. 2020 Oct 1;203:112601.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4