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Antitumor agent-58

CAT: 0804-HY-146323Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146323Size:1 Each
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Description
Antitumor agent-58 (Compound C18) is an anti-tumor agent. Antitumor agent-58 effectively inhibits colony formation and cell migration of MGC-803 cells. Antitumor agent-58 induces apoptosis of MGC-803 cells through activation of the p38 and JNK signaling pathways. Antitumor agent-58 induces mitochondrial dysfunction of MGC-803 cells. Antitumor agent-58 effectively inhibits tumor growth of xenograft model bearing MGC-803 cells[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-58.html
Solubility
10 mM in DMSO
Smiles
CC1=NC2=NC(SCC3=CC=C(C=C3)C(F)(F)F)=NN2C(N4CC[C@H]([C@H](C4)N(C5=NC=NC6=C5C=CN6)C)C)=C1
Molecular Formula
C27H28F3N9S
Molecular Weight
567.63
References & Citations
[1]Shi XJ, et al. Discovery of tofacitinib derivatives as orally active antitumor agents based on the scaffold hybridization strategy. Eur J Med Chem. 2020 Oct 1;203:112601.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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