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Antitumor agent-69

CAT: 0804-HY-146187Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146187Size:1 Each
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Description
Antitumor agent-69 (compound 12) is a potent inhibitor of protein-protein interaction between DOT1L and MLL-AF9/MLL-ENL, with Kis of 9 nM and 109 nM for AF9 and ENL, respectively. Antitumor agent-69 exhibits anticancer cellular activitiy[1].
CAS Number
2417651-42-2
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-69.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(CCC1)C(CCC(C)C)=O)N[C@@H](C(C)C)C(N[C@@H](CNC)C(N[C@@H](CC2CCCC2)C(N[C@H](C3=NC4=CC=CC(C5=CC=CC=C5)=C4N3)C)=O)=O)=O
Molecular Formula
C43H62N8O5
Molecular Weight
771.00
References & Citations
[1]Yuan Y, et, al. Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. J Med Chem. 2022 Jun 9;65 (11) :7770-7785.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DOT1L

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